Methylation Support Plan – Care Instructions

1. Start with the core product: Homocysteine Supreme

  • Begin with ½ dose daily for the first 3–5 days, then increase to the full recommended dose as tolerated.

  • This provides the activated B vitamins and TMG needed to support healthy methylation, balanced homocysteine, and optimal detox pathways.

2. Add NAC if you want additional detox and antioxidant support

  • Take NAC once daily, ideally in the evening or with food if sensitive.

  • NAC helps your body produce glutathione, reducing oxidative stress and improving methylation efficiency.

3. Add magnesium based on your symptoms and timing needs

  • Magnesium glycinate (evening option)

    • If you experience tension, poor sleep, or feel overstimulated with methyl donors, take magnesium glycinate in the evening.

    • Start with one capsule and increase gradually as needed.

    • Magnesium glycinate supports enzyme function, promotes relaxation, and may improve tolerance to methylation.

  • Magnesium malate (daytime option)

    • If your primary goals are daytime energy support, muscle function, or metabolic resilience, magnesium malate may be preferred earlier in the day.

    • Magnesium malate supports enzymatic activity involved in energy metabolism and one-carbon pathways, making it a helpful adjunct in methylation support—particularly for daytime use.

  • You do not need both forms unless specifically indicated.

4. Add Omega-3 Fatty Acids for inflammation balance and brain support

  • Take omega-3s with a meal, ideally in the morning, to support mood, cognitive clarity, and cell health involved in methylation.

5. Stay consistent for 6–8 weeks before reassessing

  • Methylation improvements take time; most people notice better energy, clearer thinking, and a more balanced mood after several weeks of steady use.

6. Recheck homocysteine and related markers at 6–8 weeks

  • Contact me to order functional lab testing through Fullscript to check:

    • Homocysteine

    • B12 and folate

    • Liver enzymes (ALT/AST)

    • Your results will guide whether you continue, adjust, or simplify your routine.

7. Start low and increase gradually

  • If you tend to feel wired, anxious, or overstimulated with B-vitamins, take it slow:

    • Start with ½ dose

    • Increase the dose every 3–5 days, until you reach the full dose

    • Reduce or pause if you feel restless or overstimulated

    • This helps your body adapt comfortably.

8. What to expect

  • Weeks 1–2

    • Smoother energy

    • Clearer thinking

    • Less tension

  • Weeks 3–6

    • More stable mood

    • Better stress tolerance

    • Improved detox support

  • Week 6–8

    • Lab improvements (homocysteine, B vitamins)

    • Ability to fine-tune your dose

9. Optional: Keep your plan simple

  • You do not need all the add-ons.

  • Most people do well starting with only Homocysteine Supreme, and optionally adding NAC, magnesium, or omega-3s based on symptoms or goals.